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KMID : 0369820090390030161
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Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 3 p.161 ~ p.166
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Specification and Testing Method of WHW ex. for Chronic Renal Failure
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Cho Cheong-Weon
Kang Jong-Seong
So Jae-Woo
Kang Hee-Chul
Seo Chang-Gyo
Lim Ji-Ho
Park Yong-Ki
Lee Young-Jae
Kim Young-Ho
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Abstract
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This study is to specify the criteria and testing methods of WHW extract which has a potency as a therapeutic agent for chronic renal failure. The determination of specifications of WHW extract is mostly important because of the quality assurance. Three batches of WHW extract were obtained by the extraction at 98°C for 3 hr using water from mixture of 15 herbal medicines including Codonopsis Pilosulae Radix, Salviae Radix, Pinelliae Rhizoma, Coptidis Rhizoma, Evodiae Fructus, Epimedii Herba, Rhei Rhizoma, Perillae Herba, Glycyrrhizae Radix, Artemixiae capillaris Herba, Alimatis Rhizoma, Hoelen, Atractylodies Rhizoma alba, Polyporus and Cinnamomi Ramulus, subsequently, vaccum-dried for 15 hr. The yield of WHW extracts was 24.53% on the average. The identification of each herbal medicine of WHW extract was performed by modification of Korean Pharmacopeia IX (KP IX). The assay of WHW extract was performed using standard such as berberine, icariin, glycyrrhizin, and cinnamic acid of indicative herbal medicines by modification of KP IX, too. As well as, paticle size classification test was carried out to indicate the boundary of particle size of WHW extract and the particle size of WHW extract more than 50% showed the 140 μm. Taken together, WHW extract could be prepared reproducibly and assurable if follows the presented extraction and drying steps and its specifications were satisfied with the indicated criteria.
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KEYWORD
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Herbal medicine, WHW extract, chronic renal failure, specification, quality control, quality assurance
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